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Neuroscience Basics: GABA Receptors and GABA Drugs, Animation


Gamma-aminobutyric acid, or GABA, is the primary
INHIBITORY neurotransmitter in the mature brain. It REDUCES neuronal activity of target cells
through its binding to GABA receptors present on the cell surface. Nearly half of all synapses of the brain express
some kind of GABA receptor and are thus responsive to GABA. There are at least 3 types of GABA receptors:
GABA-A, GABA-B and GABA-C. GABA-A and GABA-C are ligand-gated chloride channels. Upon transmitter binding, they open and allow
chloride ions to flow into the neuron, making it more NEGATIVE, or HYPER-polarized, and
thus LESS likely to generate action potentials. GABA-B acts through a G-protein to activate
potassium channels, which allow positively-charged potassium to flow OUT of the cell, again resulting
in membrane HYPER-polarization and a subsequent decrease in neuron responsiveness. GABA is believed to play a major role in controlling
neuronal hyperactivity associated with fear, anxiety and convulsions. GABA-A receptor is composed of 5 protein subunits. In addition to binding sites for GABA, it
has allosteric binding sites for other substances known as GABA modulators. These are molecules that can INCREASE or DECREASE
the action of GABA, but have no effect in the absence of GABA. For example, benzodiazepines, a class of drugs
used to treat anxiety, bind to GABA-A receptor and facilitate its binding to GABA, thus potentiating
GABA inhibitory effect. Other positive modulators include barbiturates,
alcohol, propofol, among others. Examples of negative modulators are convulsants,
such as Flumazenil. Flumazenil reverses the effects of benzodiazepines
by competing with them at the same binding site on GABA-A.

36 Comments

  1. Hicham Bougaa
    Hicham Bougaa April 24, 2017

    سلام عليك ++++++

  2. islam ibrahim
    islam ibrahim April 24, 2017

    wonderful

  3. Sami Aziz
    Sami Aziz April 24, 2017

    anything in dentistry, thank you

  4. Alila Medical Media
    Alila Medical Media April 25, 2017

    Follow us on Twitter https://twitter.com/AlilaMedical for instant notification of our new videos!

  5. Antoine PVT
    Antoine PVT April 26, 2017

    Thank you it's exactly what we need to understand quickly.
    Please continue !

  6. sai varun
    sai varun April 28, 2017

    excellent, action of inhibitory neurotransmitters and its drugs

  7. Gene Murphy
    Gene Murphy May 3, 2017

    Good morning, I was really hoping you would be able to provide a video elaborating on what happens when your gaba receptors become totally down regulated from the use of Benzodiazipens and you loosing over 30% of nuro transmissions along with creating the extreme, horrific, debilitating symptoms compared to the brief, mild symptoms of down regulation of the gaba receptor from alcohol.

    There are well over 160,000 suicides a year from the physical and mental anguish symptoms that is created from the loss of all gaba due to down regulation of the gaba receptors from benzo use and millions of others all over the world living with years of serious debilitating symptoms while they wait for the adaptation of the receptors to reform and or up regulate.

    There is even a World wide awareness campaign going on to pressure the DEA to regulate the use of benzos.

    My cousin, after years of medical testing all over the country has been suffering from this condition for over three years since discontinuing the use of the drug and can do nothing but crawl around the house and scream for someone to kill him.

    Also if alcohol binds to the same gaba receptors why does it only take a few weeks after many years of abuse to recover and regain homeostasis while it takes only a few months of using the benzo drugs as prescribed to reach total down regulation and years to recover and restore homeostasis?

    I am willing to pay or donate what ever funds it will require to have someone explain this as best as can be understood.

    Thank you so much for all your helpful work offered here on line, please keep it coming.

    Thanks again, God Bless, Gene Murphy

  8. Firas Sabbagh
    Firas Sabbagh May 21, 2017

    Great

  9. Tony Escobar
    Tony Escobar June 8, 2017

    can you explain schizoaffective disorder at the brain level?????

  10. DrDavid Hakeem
    DrDavid Hakeem July 8, 2017

    we need more info about the flumazine and the gaba B like Baclofen thanks

  11. Raro Fr
    Raro Fr August 2, 2017

    thank you very much.
    please make the videos with much more details .

  12. Sabrina Chanel
    Sabrina Chanel October 31, 2017

    Quick and concise, very good!

  13. Li Hamedi
    Li Hamedi November 27, 2017

    Would you kindly show us what negative side effects Marijuana has?
    Thanks

  14. Sumasrikanth Sumasrikanth
    Sumasrikanth Sumasrikanth December 21, 2017

    Please make a vedio abt SNS n PSNS

  15. Suzanne Porter
    Suzanne Porter January 23, 2018

    Medical Marijuana has been the best help controlling my epileptic seizures. What I would like to learn more about is how serotonin helps decrease epileptic seizures in the spring and summer.  Thanks for your time.

  16. Lokendra Singh
    Lokendra Singh March 16, 2018

    thank you very much teaching for me

  17. nicole webb
    nicole webb April 24, 2018

    I like the way this was explained. Can you please make a video that helps adolescent's understand the effects of Benzos on the receptors. Especially for teens who abuse Xanax.

  18. Alila Medical Media
    Alila Medical Media May 29, 2018

    Help us make more videos like this! Support us on Patreon and get FREE downloads and other great rewards: https://www.patreon.com/AlilaMedicalMedia/posts
    Thank you so much!

  19. Dr Vishal Garg
    Dr Vishal Garg August 3, 2018

    Actual explantion

  20. Aaron Maloney
    Aaron Maloney September 2, 2018

    Benzodiazepines do not bind with your receptors , instead they regulate how the Brian produces that chemical naturally .. potentially causing minor brain damage & psychological differences in a person .

  21. Ashima Saraf
    Ashima Saraf September 28, 2018

    Antihistaminss….antiepileptics

  22. しずか ともこDemonic Angel
    しずか ともこDemonic Angel October 6, 2018

    Very helpful. Thank you so much

  23. T. Rene
    T. Rene October 16, 2018

    Best breakdown so far. Thank you for the vid, helped a lot.

  24. KUBRA Kubra
    KUBRA Kubra December 1, 2018

    QUICK and CONCISE for PHARMACY beginners…Here u go with one more SUBSCRIBER;)

  25. Holly Fabiani
    Holly Fabiani December 3, 2018

    What about muscimol?

  26. Selalu Bersyukur
    Selalu Bersyukur December 9, 2018

    Can you explain all about ion channel that can refer to medicine action in our body

  27. Shahid Rashid
    Shahid Rashid December 21, 2018

    thanks. ….it's very helpful

  28. Blend Fathullah
    Blend Fathullah December 29, 2018

    Very good but toooooooo fast

  29. Brian Piper
    Brian Piper January 27, 2019

    This is mostly an accurate video. The good folks that put together nomenclature have got their erasers out for "GABA-C" receptors which are now known as GABA-Arho.

  30. Tinotenda Mavu
    Tinotenda Mavu May 16, 2019

    explanation was good.cover also effects on the brain

  31. Chandra Mouli
    Chandra Mouli July 8, 2019

    please do a video on seretonin signalling pathway

  32. nithya m
    nithya m July 27, 2019

    Please cover about PET scans

  33. Dibya Biswal
    Dibya Biswal August 10, 2019

    General anesthesia mechanism of action?

  34. Kiran Sawant
    Kiran Sawant September 9, 2019

    Good one !

  35. Dejan Markovic
    Dejan Markovic September 12, 2019

    What if i take gaba supplements during the day and a bzd before sleep? Do they cancel each other out, or is the effect synergic? Thank you, already subscribed.

  36. mohammad sarfraz
    mohammad sarfraz September 13, 2019

    very clear explaination

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